Individual risk factors for cervical cancer that are potentially important and are not recorded in screening registries, can be retrieved via a questionnaire. Such patient-derived risk factors can be used in a screening program by entering them in a digital risk-based screening platform. These factors include symptoms, smoking and use of oral contraceptives for example and are expected to provide further refinement of individualized risk profiles. To incorporate patient-derived risk factors in our profiles for cancer and precancer, we will conduct meta-analyses and prospectively collect data via the electronic questionnaires added to the digital platform for risk-based screening.
Besides a risk profile for cancer and precancer, we also need to develop a risk profile for obstetric complications in women treated for cervical precancer. The risk of treatment-related obstetric complications will be quantified by means of an individual patient data pooled analysis.