Digitalization will greatly contribute to the implementation of risk-based screening. Patient-derived risk factors can be added to the risk profile and personalized recommendations can be provided by the screening program without logistic hurdles. Furthermore, digital, personalized screening invitations via a mobile or digital platform are expected to enhance the coverage of a screening program, in particular when combined with an option for self-collection of a cervical specimen as shown in our previous Coheahr project (Ref 1, 2, 3). The platform will consist of two components: a front-end (mobile application) harvesting data and communicating at the individual level; and a back-end integrating data with historical data and implementing risk models. This will enable tracking and assessment of each step involved in the risk stratification process, including the identification of relevant variables. The software framework will be open source and free-to-use to support implementation in screening programs. The platform will be co-created with health professionals and patients via involvement of the ESGO-ENGAGe network (European Network of Gynaecological Cancer Advocacy Groups) and screen-eligible women. A pilot demonstration trial of the platform will be conducted amongst all women within the organized screening program of the Stockholm region (about 150,000 women) to assess the impact of the digital invitational system on screening attendance, the acceptability of our approach and the cost savings that can be realized by risk-based screening.